| Welcome to the Laboratory of Fred
Ausubel in the Department
of Molecular Biology at The
Massachusetts General Hospital a joint department with the Department
of Genetics at the Harvard
Medical School. The laboratory's primary interest is in identifying
and characterizing the molecular aspects of the process of signal transduction in
prokaryotes and in hosts that interact with prokaryotes, from the discovery of
virulence factors in bacteria and fungus to host defense responses in plants and
worms. These Pathogen-Host interactions are explored through a variety of
ways, both experimentally and computationally.
The laboratory is using whole genome approaches to investigate these
aspects of microbial pathogenesis and host defense responses. We are particularly
interested in elucidating those aspects of pathogenesis that are similar
irrespective of the pathogen and the host. We also develop software and
databases for genome bioinformatics which integrate our diverse areas
of study. [Research
Overview]
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